HAV  is  a  positive  RNA  virus, a  unique  member  of  picornaviridae.Its. Its  transmission  depend primarily on serial transmission from person to person by the fecal-oral route. Although hepatitis A  is  not  ordinarily  a  sexually  transmitted  disease, the  infection  rate  is  high  among  male homosexuals, as result of oral-anal contact. The anti-HAV IgG is produced in the early stage of infection, its titer in serum or plasma has been quite high at the onset of serum and reach the peak after 2-3 months. The lgG antibody is a protective antibody and can be maintained for a long time. The emergence of anti-HAV IgG can’t make a HAV diagnosis unless anti-HAV IgM exist at the same time. The presence of anti-HAV IgG,but no anti-HAV IgM is a marker of infected HAV and acquired immunity. The presence of specific anti-HAV IgM in blood samples suggests acute or recent HAV infection. The  IgM antibody rapid increases in titer over a period of 4-6 weeks post infection, and then declines to non-detectable levels within 3 to 6 months in most patients. The HAV IgG/IgM Rapid Test Device is to be used to detect IgG/IgM anti-HAV in less than 20 minutes by trained personnel, without cumbersome laboratory equipment

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